Cell Cycle/Checkpoint

5-Aminosalicylic acid-d3 is the deuterium labeled 5-Aminosalicylic Acid.

Tubulin inhibitor 30 (Compound 15) is a tubulin assembly inhibitor with an IC50 of 0.52 μM.

Aurora Kinases-IN-3 (Compound 15a) is an orally active AURKB inhibitor that elicits an AURKB-suppressive activity by disrupting the mitotic localization of AURKB.

DRP1i27 didrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1).

Dynamin IN-1 is a potent dynamin inhibitor with an IC50 value of 1.0 µM.

Clathrin-IN-4 (compound 8b), a Wiskostatin analogue, is a potent inhibitor of clathrin mediated endocytosis with an IC50 of 2.1 μM.

PRT062607 (P505-15) acetate is an orally available Syk inhibitor (IC50: 1 nM) that inhibits inflammation and induction Apoptosis.

EAPB 02303 is a microtubule-disrupting agent and inhibitor.

MYC-RIBOTAC is a ribonuclease-targeting chimera (RIBOTAC) to MYC internal ribosome entry site (IRES).

MC-EVCit-PAB-MMAE (Linker-Payload 11) is a drug-linker conjugates for ADC.

MARK4 inhibitor 2 is an inhibitor of microtubule affinity-regulating kinase 4 (MARK4) with an Km of 6.3×10 7 and an IC50 of 0.82 μM.

MAPK4 inhibitor 3 (compound 23b) is an inhibitor of MAPK4 with an IC50 value of 1.01 μM.

FC-11 is a Tubulin inhibitor that effectively inhibits tumor growth in mice.

Tubulin polymerization-IN-55 is a potent inhibitor of Tubulin Polymerization.

Tubulin polymerization-IN-56, an indazole derivative, is a potent tubulin polymerization inhibitor through interacting with the colchicine site, resulting in cell cycle arrest and cellular apoptosis.

Tubulin polymerization-IN-47 (Compound 4h) is a tubulin polymerization inhibitor and mitotic inhibitor.

NBI-961 is a potent NEK2 inhibitor that inhibits proteasomal degradation.

JAB-2485 is a potent and selective Aurora kinase A (AURKA) inhibitor, with an IC50 of 0.33 nM.

EGFR/AURKB-IN-1 (compound 7) is a dual-targeted EGFR/AURKB inhibitor, and inhibits the phpsphorylations of L858R EGFR and AURKB with IC50s of 0.07 and 1.1, respectively.

PC5-VC-PAB-MMAE consists the ADCs linker (PC5-VC-PAB) and potent tubulin inhibitor (MMAE).

Trilexium (TRX-E-009-1) is a third-generation of benzopyran structurally related to TRX-E-002-1.

PLK1/BRD4-IN-5 (Compound SC10) is an orally active PLK1 and BRD4 inhibitor with IC50 values of 0.3 nM and 60.8 nM, respectively.

MC-Val-Cit-PAB-Ispinesib (Compound 509) is a potent inhibitor of Eg5.

TAM557 TFA is a cytotoxic tubulysin compounds, which is modified to be used for conjugation to transport vehicles that are targeting molecules.