DNA Damage/DNA Repair

3'-O-Methylguanosine is a methylated nucleoside analogs and a RNA chain terminator.

CTX-712 is a potent CDC2 like kinase (CLK) inhibitor with an IC 50 value of 1.4nM.

1-Methylinosine is a modified nucleotide found at position 37 in tRNA 3' to the anticodon of eukaryotic tRNA.

MC-DOXHZN ((E/Z)-Aldoxorubicin) hydrochloride is an albumin-binding prodrug of Doxorubicin (DNA topoisomerase II inhibitor), with acid-sensitive properties.

6-O-Methyl Guanosine is a modified nucleoside.

3'-Azido-3'-deoxy-5-fluorocytidine (Compound 12) is a cytidine derivative.

3-Methylcytidine, a urinary nucleoside, can be used as a biomarker of four different types of cancer: lung cancer, gastric cancer, colon cancer, and breast cancer.

N2-methylguanosine is a modified nucleoside that occurs at several specific locations in many tRNA's.

BSJ-03-123 is a PROTAC connected by ligands for Cereblon and CDK as a potent and novel CDK6-selective small-molecule degrader.

PROTAC PARP1 degrader is a bifunctional small molecule composed of a PARP1-binding ligand covalently linked via a linker to an E3 ubiquitin ligase ligand, which can potently induce PARP1 cleavage and programmed cell death.

5'-O-DMT-2'-O-TBDMS-rI is a modified nucleoside.

2′,3′-Di-O-acetylguanosine is a nucleoside analog.

CDK4/6-IN-11 is a potent PROTAC CDK4/6 degrader.

Nesuparib is a potent inhibitor of PARP.

FT895 is an effective selective inhibitor of histone deacetylase 11 (HDAC11), with an IC 50 value of 3nM .

R-10015, a broad-spectrum antiviral compound for HIV infection, acts as a potent and selective inhibitor of LIM domain kinase (LIMK) and binds to the ATP-binding pocket, with an IC50 of 38 nM for human LIMK1.

4-Hydroxybenzyl alcohol is a phenolic compound widely distributed in various kinds of plants. Anti-inflammatory, anti-oxidant, anti-nociceptive activity. Neuroprotective effect. Inhibitor of tumor angiogenesis and growth.

N6-Etheno 2'-deoxyadenosine is a reactive oxygen species (ROS)/reactive nitrogen species (RNS)-induced DNA oxidation product, used as a biomarker to evaluate chronic inflammation and lipid peroxidation in animal or human tissues.

TFMB-(S)-2-HG is a potent inhibitor of the 5'-methylcytosine hydroxylase TET2. TFMB-(S)-2-HG also inhibits the EglN prolyl hydroxylases. TFMB-(S)-2-HG has the potential for the research of acute myeloid leukemia (AML).

CDK9-IN-8 is a highly effective and selective CDK9 inhibitor with an IC50 of 12 nM.

STL127705 (Compound L) is a potent Ku 70/80 heterodimer protein inhibitor with an IC50 of 3.5 μM. STL127705 interferes the binding of Ku70/80 to DNA and by inhibits the activation of the DNA-PKCS kinase. STL127705 shows antiproliferative and anticancer activity. STL127705 induces apoptosis.

BC-1471 is a STAMBP deubiquitinase inhibitor with an IC 50 of 0.33μM.

CDK9-IN-13 (compound 38) is potent and selective CDK9 inhibitor, with an IC50 of <3 nM. CDK9-IN-13 exhibits short half-lives in rodents.

USP7-IN-3 (Compound 5) is a potent and selective allosteric ubiquitin-specific protease 7 (USP7) inhibitor.