DNA Damage/DNA Repair

1,2-O-Isopropylidene-5-O-p-toluoyl-a-D-xylofuranose is a purine nucleoside analogue. Purine nucleoside analogues have broad anti-tumor activity and target malignant tumors in the inert lymphatic system. The anticancer mechanism in this process depends on inhibiting DNA synthesis, inducing apoptosis (cell death), etc.

3'Ome-m7GpppAmpG ammonium is a trinucleotide cap analog containing locked nucleic acid (LNA) molecules. It has significant translation efficiency and can be used as a potential molecular biology tool in the fields of mRNA vaccines and mRNA transfection, such as protein production, gene therapy, and anti-cancer immunity.

4-Thio-2'-deoxyuridine is a purine nucleoside analogue. Purine nucleoside analogues have broad anti-tumor activity, targeting inert lymphatic system malignancies. The anticancer mechanism in this process depends on inhibiting DNA synthesis and inducing cell apoptosis.

Adenine-13C is a 13C-labeled Adenine. Adenine (6-Aminopurine) is a purine and one of the four nucleobases in DNA. Adenine is a chemical component of both DNA and RNA. It plays an important role in cellular respiration, the formation of ATP, coenzymes NAD and FAD, as well as protein synthesis.

Adenosine-d2 is the deuterated form of adenosine. Adenosine (adenine riboside) is a commonly occurring endogenous secretion that acts through four G protein-coupled receptors (A1, A2A, A2B, and A3). Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.

Anticancer agent 73 (compound CIB-3b) is an anticancer drug that targets TAR RNA binding protein 2 (TRBP) and disrupts its interaction with Dicer. Anticancer agent 73 can rebalance the expression profile of oncogenic or tumor-suppressive miRNAs. Anticancer agent 73 has inhibitory effects on the proliferation and metastasis of hepatocellular carcinoma (HCC) cells both in vitro and in vivo.

ATR-IN-4 is an effective ATR inhibitor. ATR-IN-4 inhibits the growth of human prostate cancer cells DU145 and human lung cancer cells NCI-H460, with IC50 values of 130.9 nM and 41.33 nM, respectively (excerpted from patent CN112142744A, compound 13).

AZ5576 is a potent and highly selective inhibitor of CDK9 (IC50:

BAY-728 can be used as a negative control for BAY-805. BAY-805 is an effective selective inhibitor of USP21.

BAY-805 is a selective inhibitor of the ubiquitin-specific protease USP21. BAY-805 has high selectivity for deubiquitinating enzyme (DUB) targets, kinases, proteases, and other common off-target enzymes.

Bisantrene dihydrochloride is an effective anticancer agent that exerts cytotoxicity by affecting DNA intercalation. Bisantrene dihydrochloride targets the topoisomerase II of eukaryotes. Bisantrene dihydrochloride is a substrate for MDR1.

BRD7586 is a small molecule inhibitor of SpCas9's cellular permeability. It is the smallest known anti-CRISPR inhibitor.

CDK12-IN-5 is a pyrazole-triazine compound that is an effective inhibitor of CDK12, with an IC50 of 23.9 nM at high ATP (2 mM). CDK12-IN-5 has no effect on CDK2/Cyclin E (IC50=173 μM) and CDK9/Cyclin T1 (IC50=127 μM) at high ATP (2 mM) (WO2021116178A1).

CDK1-IN-2 is a CDK1 inhibitor (IC50: 5.8 μM).

CDK2-IN-13 (Compound 15) is a CDK2 inhibitor with an IC50 value of 12 μM. CDK2-IN-13 can be used for cancer research.

CDK4/6-IN-15 is an orally effective and selective CDK4/6 inhibitor. It can effectively inhibit cancer cell growth. CDK4/6-IN-15 blocks the cell cycle in the G1 phase and inhibits phosphorylation of retinoblastoma tumor suppressor protein (Rb) at S780 site and E2 factor (E2F)-regulated gene expression in retinoblastoma tumors.

CLK1-IN-2 is a metabolically stable inhibitor of Clk1. It has selective activity against Clk1 with an IC50 value of 1.7 nM. CLK1-IN-2 can be used for research on tumors, Duchenne muscular dystrophy, and viral infections such as HIV-1 and influenza.

CM03 is an effective DNA G-quadruplex (G4s) binding molecule. CM03 can stabilize G4s, downregulate more genes containing G4s, and increase the incidence of double-stranded break events (DSBs) caused by DNA and chromatin structural torsion strain. CM03 has selective effects on pancreatic cancer cells.

CPS2 is a highly efficient, selective, and irreversible PROTAC CDK2 degrader (IC50= 24 nM). CPS2 can be used for research on acute myeloid leukemia.

Crisnatol (BWA770U) is an orally effective anticancer agent and arylmethylamino-propanediol class DNA intercalator. Crisnatol exhibits in vitro cytotoxicity against human breast cancer cells, but is ineffective against normal human skin fibroblasts.

Curcolonol is a furanoid sesquiterpene that can be isolated from several herbs. It has inhibitory activity against LIM kinase 1 and can be used in breast cancer research.

DB008 is an effective selective inhibitor of PARP16 with an IC50 value of 0.27 μM and contains acrylamide electrophile. DB008 has membrane permeability and can selectively label PARP16.