DNA Damage/DNA Repair

5'-ODMT cEt G Phosphoramidite Amidite is a potent nucleic acid analog.

5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is a potent nucleic acid analog.

5'-ODMT cEt m5U Phosphoramidite Amidite is a locked nucleic acid (LNA) analog.

Akt1&PKA-IN-1 is a potent dual Akt/PKA inhibitor with IC50 values of 0.03 , 0.11 μM, and 9.8 μM for PKAa, Akt, and CDK2, respectively.

NT160 is a highly potent class-IIa HDAC inhibitor with an IC50 value of 0.046 μM.

DNL343 is a brain-penetrating activator of eukaryotic initiation factor 2B (eIF2B) that inhibits the abnormal integrated stress response (ISR).

PB94 is a selective HDAC11 inhibitor (IC50=108 nM).

PolQi2 is a Polθ inhibitor that targets and inhibits alt-EJ (alternative end-joining) repair by inhibiting the helicase domain at the N-terminus of Polθ.

CTP Synthetase-IN-1 is a potent, orally active cytidine 5'-triphosphate synthetase (CTPS) inhibitor with IC50s of 32 nM and 18 nM for human CTPS1 and human CTPS2, respectively.

3’-O-(2-Methoxyethyl)guanosine is a guanosine analogue.

5-Ethyluridine is a purine nucleoside analogue.

2-Methyladenosine is an adenosine analogue.

Casein kinase 1δ-IN-6 is a potent and selective protein kinase CK-1δ inhibitor with an IC50 of 23 nM.

1-(2-Deoxy-β-D-threo-pentofuranosyl)thymine is a thymidine analog.

Uridine 3′,5′-diphosphate (3′,5′-UDP; Compound pUp) is a competitive RNase inhibitor.

GK16S is a UCHL1 chemogenomic probe.

12R-LOX-IN-2 (compound 7b) is an inhibitor of 12R-lipoxygenase (12R-LOX).

RNase L-IN-1 (compound 17a) is an inhibitor of RNase L, or Ribonuclease L.

RNase L-IN-1 (compound 17a) trihydrochloride is an inhibitor of RNase L or ribonuclease L.

5-Fluoro-2′-deoxy-UTP can be used as a substrate for DNA synthesis.

DMTr-5-fluoro-2'-deoxycytidine-phosphoramidite (compound 1B) is a phosphoramidite of 5-Fluoro-2'-deoxycytidine.

OTUB2-IN-1, a specific inhibitor of OTUB2 (KD: ~12 μM), reduces PD-L1 protein expression in tumor cells and inhibits tumor growth by promoting robust intra-tumor infiltration of cytotoxic T lymphocytes (CTL) .

2,4-D-13C6 is the 13C-labeled 2,4-D.

7-Methyl-guanosine-5'-triphosphate (m7GTP) sodium is a guanosine 5'-phosphate.