GLPBio

DNA Damage/DNA Repair

Research Areas

Products Related to DNA Damage/DNA Repair(1975)

  • GC73073 structure
    GC730735-Aza-4'-thio-2'-deoxycytidine
    CAS: 169514-76-5
    Purity: >99.00%

    5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd) is an orally active DNA metltransferase I (DNMT1) inhibitor.

  • GC73079 structure
    GC73079Datopotamab deruxtecan
    CAS: 2238831-60-0
    Purity: >98.00%

    Datopotamab deruxtecan is a TROP2-targeting antibody-drug conjugate (K D =0.74nM).

  • GC73086 structure
    GC73086CDK4/6-IN-15 hydrochloride
    Purity: >99.00%

    CDK4/6-IN-15 drochloride is an orally active and selective CDK4/6 inhibitor.

  • GC73100 structure
    GC73100Senexin C
    CAS: 2375554-02-0
    Purity: >98.00%

    Senexin C is a selective and orally active CDK8/19 inhibitor.

  • GC73112 structure
    GC73112JPS014 TFA
    Purity: >98.00%

    JPS014 TFA is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC).

  • GC73113 structure
    GC73113JPS016 TFA
    Purity: >98.00%

    JPS016 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC).

  • GC73118 structure
    GC73118EB1
    CAS: 42951-68-8
    Purity: >99.00%

    EB1 is the inhibitor of kinases MNK with IC50s of 0.69 μM (MNK1) and 9.4 μM (MNK2).

  • GC73122 structure
    GC73122Val-Ala-PABC-Exatecan
    CAS: 2845164-91-0
    Purity: >98.00%

    Val-Ala-PABC-Exatecan is a Drug-Linker Conjugates for ADC，consiting of a cleavable Tesirine linker (Val-Ala-PABC) and Exatecan (topoisomerase I inhibitor，).

  • GC73123 structure
    GC73123Val-Ala-PABC-Exatecan trifluoroacetate
    CAS: 2928571-45-1
    Purity: >98.00%

    Val-Ala-PABC-Exatecan trifluoroacetate is a Drug-Linker Conjugates for ADC, consiting of a cleavable Tesirine linker (Val-Ala-PABC) and Exatecan (topoisomerase I inhibitor, ).

  • GC73130 structure
    GC73130Basroparib
    CAS: 1858179-75-5
    Purity: >98.00%

    Basroparib is a potent poly (ADP-ribose) polymerase (PARP) inhibitor, with antineoplastic activity.

  • GC73132 structure
    GC73132Mal-PEG8-Val-Ala-PAB-Exatecan
    CAS: 2679821-39-5
    Purity: >99.00%

    Mal-PEG8-Val-Ala-PAB-Exatecan (Compound 9b) is an antibody-drug conjugate linker (ADC linker) that binds to Nectin-4 polypeptides conjugated to chemotherapeutic agents.

  • GC73136 structure
    GC73136VPC-70063
    CAS: 13571-44-3
    Purity: >99.00%

    VPC-70063 is a potent Myc-Max inhibitor with an IC50 value of 8.9 μM for Myc-Max transcriptional activity inhibition.

  • GC73156 structure
    GC73156USP1-IN-3
    CAS: 2821749-58-8
    Purity: >99.00%

    USP1-IN-3 is a selective USPI inhibitor.

  • GC73158 structure
    GC73158L2H2-6OTD diformic
    Purity: >99.00%

    L2H2-6OTD acetate contains one to four G-quadruplex binding loops and is a telomere inhibitor analog.

  • GC73166 structure
    GC73166U7D-1
    Purity: >99.00%

    U7D-1 is a first-in-class potent and selective USP7 (ubiquitin-specific protease 7) PROTAC degrader, with a DC50 of 33 nM in RS4;11 cells.

  • GC73170 structure
    GC73170eIF4A3-IN-9
    CAS: 1402931-71-8
    Purity: >99.00%

    eIF4A3-IN-9 (compound 57) is a silvestrol analogue.

  • GC73171 structure
    GC73171eIF4A3-IN-12
    CAS: 1402931-76-3
    Purity: >99.00%

    eIF4A3-IN-12 (compound 62) is a silvestrol analogue.

  • GC73172 structure
    GC73172eIF4A3-IN-16
    CAS: 1402931-74-1
    Purity: >98.00%

    eIF4A3-IN-16 (compound 60) is a silvestrol analogue.

  • GC73177 structure
    GC73177USP7-IN-10 hydrochloride
    Purity: >99.00%

    USP7-IN-10 drochloride (compound 1) is a potent ubiquitin-specific protease 7 (USP7) inhibitor, with an IC50 of 13.39 nM.

  • GC73179 structure
    GC731795'-ODMT cEt N-Bz A Phosphoramidite (Amidite)
    CAS: 1197033-19-4
    Purity: >98.00%

    5'-ODMT cEt N-Bz A Phosphoramidite Amidite is a locked nucleic acid (LNA) analogue.

  • GC73183 structure
    GC73183CDK8-IN-12
    CAS: 2613307-67-6
    Purity: >99.00%

    CDK8-IN-12 is an orally active, potent CDK8 inhibitor with a Ki of 14 nM.

  • GC73184 structure
    GC73184OUL232
    CAS: 943119-42-4
    Purity: >99.00%

    OUL232 is a potent inhibitor of mono-ARTs PARP7, PARP10, PARP11, PARP12, PARP14, and PARP15.

  • GC73189 structure
    GC73189MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan
    CAS: 2414254-51-4
    Purity: >97.00%

    MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan is a agent-linker conjugates for ADC, consisting Exatecan.

  • GC73190 structure
    GC73190MC-Gly-Gly-Phe-Gly-(S)-Cyclopropane-Exatecan
    CAS: 2414254-52-5
    Purity: >95.00%

    MC-Gly-Gly-Phe-Gly-(S)-Cyclopropane-Exatecan is a agent-linker conjugates for ADC, consisting Exatecan.