Chromatin/Epigenetics
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Epigenetics
Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.
Research Areas
- Bromodomain(44)
- Aurora Kinase(74)
- DNA Methyltransferase(43)
- HDAC(250)
- Histone Acetyltransferases(100)
- Histone Demethylases(120)
- Histone Methyltransferase(278)
- HIF(127)
- JAK(190)
- PARP(162)
- Pim(35)
- Protein Ser/Thr Phosphatases(23)
- RNA Polymerase(4)
- Sirtuin(88)
- Sphingosine Kinase-2(1)
- Polycomb repressive complex(2)
- SUMOylation(3)
- PAD(20)
- Epigenetic Reader Domain(295)
- MicroRNA(33)
- Protein Arginine Deiminase(17)
- Chromodomain(1)
- Citrullination(20)
- DNA/RNA Demethylation(2)
- DNA/RNA Methylation(8)
- Histone Deacetylation(43)
- Histones/Histone Peptides(62)
- PHD Domains(1)
- Tandem Tudor & Tudor-like Domains(1)
- PRMT(2)
- Readers(1)
- Small Interfering RNA (siRNA)(16)
- METTL3(4)
- WDR5(8)
- TET Protein(2)
- HuR(2)
- SF3B1(2)
Products Related to Chromatin/Epigenetics(1948)
- GC81882PROTAC CARM1 degrader-1 TFAPurity: >98.00%
PROTAC CARM1 degrader-1 TFA is a highly selective CARM1 PROTAC degrader, with a DC 50 of 8.1 nM in MCF‑7 cells.
- GC81890Temozolomide-¹⁵NPurity: >98.00%
Temozolomide - 15 N (NSC 362856- 15 N) is the 15 N-labeled Temozolomide.
- GC90195Posaconazole-d5CAS: 2649530-57-2Purity: >98.00%
An internal standard for the quantification of posaconazole
- GC91565GSK199 analog (hydrochloride)CAS: 2048226-46-4Purity: >95.00%
GSK199 analog is an inhibitor of peptidyl arginine deiminase 4 (PAD4) and a derivative of the PAD4 inhibitor GSK199.
- GC91622KAT8 Inhibitor 19CAS: 28532-21-0Purity: >98.00%
KAT8 inhibitor 19 is an inhibitor of lysine acetyltransferase 8 (KAT8; IC50 = 12.1 µM).
- GN10040DehydrocorydalineCAS: 30045-16-0Purity: >98.00%
Dehydrocorydaline is one of the quaternary ammonium alkaloids from Corydalis Rhizoma.
- GN10308Chlorogenic acidCAS: 327-97-9Purity: >98.00%
Chlorogenic acid is a potent neuroprotective agent and also has antiviral,antifungal antioxidant and antitumor properties. CGA is also involved in regulating glucose and lipid metabolism and improving insulin sensitivity.
- GN10347Nicotinamide (Vitamin B3)CAS: 98-92-0Purity: >99.50%
Nicotinamide (Vitamin B3) is an amide derivative of vitamin B3 that can inhibit the activity of SIRT1 (IC 50 : 50-180 μM) and SIRT2 (IC 50 : 2 μM). Nicotinamide can also increase the levels of NAD + , ATP, and ROS in cells .
- GN10357ParthenolideCAS: 20554-84-1Purity: >98.00%
Parthenolide is an NF-κB inhibitor with IC 50 values for Eca109, KYSE-510, SiHa and MCF-7 cells of approximately 10.3, 13.3, 8.42 and 9.54µM at 48h respectively.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC81879 | NCP26 TFA | - | >99.50% | |
NCP26 TFA is an ATP-competitive ProRS inhibitor (with a K D of 271 nM in the absence of proline, and a K D of 0.35 nM in the presence of 100 μM proline). | ||||
| GC81882 | PROTAC CARM1 degrader-1 TFA | - | >98.00% | |
PROTAC CARM1 degrader-1 TFA is a highly selective CARM1 PROTAC degrader, with a DC 50 of 8.1 nM in MCF‑7 cells. | ||||
| GC81890 | Temozolomide-¹⁵N | - | >98.00% | |
Temozolomide - 15 N (NSC 362856- 15 N) is the 15 N-labeled Temozolomide. | ||||
| GC90195 | Posaconazole-d5 | 2649530-57-2 | >98.00% | |
An internal standard for the quantification of posaconazole | ||||
| GC90710 | CAY10723 (hydrochloride) | - | >95.00% | |
A PAD2 inhibitor | ||||
| GC91025 | PTD2 (trifluoroacetate salt) | - | >98.00% | |
A peptide inhibitor of WHSC1 | ||||
| GC91059 | LCC-12 (formate) | - | >98.00% | |
A copper (II) chelator and derivative of metformin | ||||
| GC91061 | UNC8153 (trifluoroacetate salt) | 2929304-61-8 | >95.00% | |
A degrader of NSD2 | ||||
| GC91083 | Tiopronin-Cysteine Disulfide | 77591-18-5 | >95.00% | |
A metabolite of tiopronin | ||||
| GC91148 | JAK Inhibitor 31 | 2891469-99-9 | >98.00% | |
A JAK2 inhibitor | ||||
| GC91389 | J27644 | - | >95.00% | |
J27644 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 10 nM). | ||||
| GC91435 | YCH1899 | - | >98.00% | |
YCH1899 is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 (IC50s = 1 It is selective for PARP1 and PARP2 over PARP3, -4, -5A, -5B, -6, -7, -10, and -12 (IC50s = 1-14.1 nM). | ||||
| GC91506 | Bayer 18 | 1251752-12-1 | >98.00% | |
Bayer 18 is a tyrosine kinase 2 (TYK2) inhibitor (IC50 = 18.7 nM). | ||||
| GC91565 | GSK199 analog (hydrochloride) | 2048226-46-4 | >95.00% | |
GSK199 analog is an inhibitor of peptidyl arginine deiminase 4 (PAD4) and a derivative of the PAD4 inhibitor GSK199. | ||||
| GC91602 | PFI-6 | 2675452-91-0 | >95.00% | |
PFI-6 is a chemical probe for the YEATS domain-containing proteins MLLT1 and MLLT3 (IC50s = 140 and 160 nM, respectively). | ||||
| GC91622 | KAT8 Inhibitor 19 | 28532-21-0 | >98.00% | |
KAT8 inhibitor 19 is an inhibitor of lysine acetyltransferase 8 (KAT8; IC50 = 12.1 µM). | ||||
| GC91689 | TG46 | 936091-15-5 | >98.00% | |
TG46 is an inhibitor of JAK2 (IC50 = 12.5 µM). | ||||
| GN10030 | Fisetin | 528-48-3 | >98.00% | |
Fisetin is a natural flavonol found in many fruits and vegetables with multiple biological activities. | ||||
| GN10040 | Dehydrocorydaline | 30045-16-0 | >98.00% | |
Dehydrocorydaline is one of the quaternary ammonium alkaloids from Corydalis Rhizoma. | ||||
| GN10114 | Oroxin A | 57396-78-8 | >98.00% | |
| GN10308 | Chlorogenic acid | 327-97-9 | >98.00% | |
Chlorogenic acid is a potent neuroprotective agent and also has antiviral,antifungal antioxidant and antitumor properties. CGA is also involved in regulating glucose and lipid metabolism and improving insulin sensitivity. | ||||
| GN10347 | Nicotinamide (Vitamin B3) | 98-92-0 | >99.50% | |
Nicotinamide (Vitamin B3) is an amide derivative of vitamin B3 that can inhibit the activity of SIRT1 (IC 50 : 50-180 μM) and SIRT2 (IC 50 : 2 μM). Nicotinamide can also increase the levels of NAD + , ATP, and ROS in cells . | ||||
| GN10357 | Parthenolide | 20554-84-1 | >98.00% | |
Parthenolide is an NF-κB inhibitor with IC 50 values for Eca109, KYSE-510, SiHa and MCF-7 cells of approximately 10.3, 13.3, 8.42 and 9.54µM at 48h respectively. | ||||
| GN10413 | Agrimol B | 55576-66-4 | >99.50% | |