Chromatin/Epigenetics
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Epigenetics
Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.
Research Areas
- Bromodomain(44)
- Aurora Kinase(74)
- DNA Methyltransferase(43)
- HDAC(249)
- Histone Acetyltransferases(98)
- Histone Demethylases(120)
- Histone Methyltransferase(277)
- HIF(127)
- JAK(188)
- PARP(162)
- Pim(35)
- Protein Ser/Thr Phosphatases(23)
- RNA Polymerase(4)
- Sirtuin(87)
- Sphingosine Kinase-2(1)
- Polycomb repressive complex(2)
- SUMOylation(3)
- PAD(20)
- Epigenetic Reader Domain(292)
- MicroRNA(33)
- Protein Arginine Deiminase(17)
- Chromodomain(1)
- Citrullination(20)
- DNA/RNA Demethylation(2)
- DNA/RNA Methylation(8)
- Histone Deacetylation(43)
- Histones/Histone Peptides(62)
- PHD Domains(1)
- Tandem Tudor & Tudor-like Domains(1)
- PRMT(2)
- Readers(1)
- Small Interfering RNA (siRNA)(16)
- METTL3(4)
- WDR5(8)
- TET Protein(2)
- HuR(2)
- SF3B1(2)
Products Related to Chromatin/Epigenetics(1939)
- GC11537MK-4827 tosylateCAS: 1038915-73-9Purity: >99.50%
MK-4827 tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC50 of 3.8 and 2.1 nM, respectively. MK-4827 tosylate leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity.
- GC12756MK-4827 hydrochlorideCAS: 1038915-64-8Purity: >99.50%
MK-4827 hydrochloride (MK-4827 hydrochloride) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. MK-4827 hydrochloride leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity.
- GC11576Tranylcypromine (2-PCPA) HClCAS: 4548-34-9Purity: >98.00%
(1S,2R)-Tranylcypromine ((1S,2R)-SKF 385) hydrochloride is a potent antidepressant agent.
- GC14490Donepezil HClCAS: 120011-70-3Purity: >99.50%
Donepezil HCl (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity.
- GC15259EPZ004777 HClCAS: 1380316-03-9Purity: >98.00%
EPZ004777 HCl is a potent, selective DOT1L inhibitor with an IC50 of 0.4 nM.
- GC13926BMS-345541CAS: 445430-58-0Purity: >99.50%
BMS-345541(free base) is a selective inhibitor of the catalytic subunits of IKK (IKK-2 IC50=0.3 μM, IKK-1 IC50=4 μM). BMS-345541(free base) binds at an allosteric site of IKK.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC11537 | MK-4827 tosylate | 1038915-73-9 | >99.50% | |
MK-4827 tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC50 of 3.8 and 2.1 nM, respectively. MK-4827 tosylate leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity. | ||||
| GC12756 | MK-4827 hydrochloride | 1038915-64-8 | >99.50% | |
MK-4827 hydrochloride (MK-4827 hydrochloride) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. MK-4827 hydrochloride leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity. | ||||
| GC17052 | MK-4827 Racemate | 1038915-75-1 | >98.00% | |
selective inhibitor of PARP1/PARP2 | ||||
| GC11576 | Tranylcypromine (2-PCPA) HCl | 4548-34-9 | >98.00% | |
(1S,2R)-Tranylcypromine ((1S,2R)-SKF 385) hydrochloride is a potent antidepressant agent. | ||||
| GC12548 | UNC 0631 | 1320288-19-4 | >99.00% | |
G9a inhibitor | ||||
| GC13103 | AZ505 ditrifluoroacetate | 1035227-44-1 | >99.50% | |
SMYD2 inhibitor | ||||
| GC13744 | AZ505 | 1035227-43-0 | >99.50% | |
SMYD2 inhibitor,potent and selective | ||||
| GC14490 | Donepezil HCl | 120011-70-3 | >99.50% | |
Donepezil HCl (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. | ||||
| GC16290 | Nafamostat hydrochloride | 80251-32-7 | >98.00% | |
Synthetic serine protease inhibitor | ||||
| GC17314 | OG-L002 | 1357302-64-7 | >99.50% | |
LSD1 inhibitor,potent and specific | ||||
| GC14151 | CBB1007 | 1379573-92-8 | >98.00% | |
LSD1 inhibitor,potent and selective | ||||
| GC15259 | EPZ004777 HCl | 1380316-03-9 | >98.00% | |
EPZ004777 HCl is a potent, selective DOT1L inhibitor with an IC50 of 0.4 nM. | ||||
| GC10676 | AK-7 | 420831-40-9 | >99.50% | |
AK-7 is a cell-permeable and brain-permeable selective SIRT2 inhibitor (IC 50 =15.5μM). | ||||
| GC11375 | UNC1999 | 1431612-23-5 | >99.50% | |
UNC1999 is an orally active inhibitor of EZH2 (IC 50 =2nM) and EZH1 (IC 50 =45nM). | ||||
| GC11424 | Valproic acid | 99-66-1 | >98.00% | |
HDAC1 inhibitor | ||||
| GC12667 | 4SC-202 | 1186222-89-8 | >99.50% | |
4SC-202 (4SC-202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). | ||||
| GC13764 | Nexturastat A | 1403783-31-2 | >98.00% | |
HDAC6 inhibitor,highly potent and selective | ||||
| GC13926 | BMS-345541 | 445430-58-0 | >99.50% | |
BMS-345541(free base) is a selective inhibitor of the catalytic subunits of IKK (IKK-2 IC50=0.3 μM, IKK-1 IC50=4 μM). BMS-345541(free base) binds at an allosteric site of IKK. | ||||
| GC14652 | MM-102 | 1417329-24-8 | >98.00% | |
MM-102 is a high-affinity, cell-permeable peptidomimetic that functions as a potent inhibitor of the MLL1-WDR5 protein-protein interaction, with an IC₅₀ of 2.4nM and a K i <1nM. | ||||