dBET57 |
| Catalog No.GC35815 |
dBET57 es un degradador potente y selectivo de BRD4BD1 basado en la tecnologÍa PROTAC. dBET57 media el reclutamiento de la ligasa de ubiquitina CRL4Cereblon E3, con una DC50/5h de 500 nM para BRD4BD1, y es inactivo en BRD4BD2.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1883863-52-2
Sample solution is provided at 25 µL, 10mM.
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dBET57 is a potent and selective degrader of BRD4BD1 based on the PROTAC technology. dBET57 mediates recruitment to the CRL4CRBN E3 ubiquitin ligase, with a DC50/5h of 500 nM for BRD4BD1, and is inactive on BRD4BD2[1]. BRD4 (BD1)|500 nM (DC50)
[1]. Nowak RP, et al. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat Chem Biol. 2018 Jul;14(7):706-714.
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)
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