Isosilybin A |
| Catalog No.GC36343 |
La isosilibina A, un flavonolignano aislado de la silimarina, tiene actividad contra el cÁncer de prÓstata (PCA). La isosilibina A inhibe la proliferaciÓn e induce la detenciÓn de la fase G1 y la apoptosis en las células cancerosas, lo que activa la maquinaria apoptÓtica en las células PCA a través del eje del receptor de andrÓgenos (AR) Akt-NF-κB.
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Cas No.: 142796-21-2
Sample solution is provided at 25 µL, 10mM.
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Isosilybin A, a flavonolignan isolated from silymarin, has anti-prostate cancer (PCA) activity. Isosilybin A inhibits proliferation and induces G1 phase arrest and apoptosis in cancer cells, which activates apoptotic machinery in PCA cells via targeting Akt-NF-κB-androgen receptor (AR) axis[1][2].
[1]. Deep G, et al. Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostatecancer LNCaP and 22Rv1 cells. Carcinogenesis. 2007 Jul;28(7):1533-42. [2]. Deep G, et al. Isosilybin A induces apoptosis in human prostate cancer cells via targeting Akt, NF-κB, and androgen receptor signaling. Mol Carcinog. 2010 Oct;49(10):902-12.
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