Isosilybin A |
| Katalog-Nr.GC36343 |
Isosilybin A, ein aus Silymarin isoliertes Flavonolignan, wirkt gegen Prostatakrebs (PCA). Isosilybin A hemmt die Proliferation und induziert G1-Phasenarrest und Apoptose in Krebszellen, was die apoptotische Maschinerie in PCA-Zellen aktiviert, indem es auf die Achse des Akt-NF-κB-Androgenrezeptors (AR) abzielt.
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Cas No.: 142796-21-2
Sample solution is provided at 25 µL, 10mM.
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Isosilybin A, a flavonolignan isolated from silymarin, has anti-prostate cancer (PCA) activity. Isosilybin A inhibits proliferation and induces G1 phase arrest and apoptosis in cancer cells, which activates apoptotic machinery in PCA cells via targeting Akt-NF-κB-androgen receptor (AR) axis[1][2].
[1]. Deep G, et al. Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostatecancer LNCaP and 22Rv1 cells. Carcinogenesis. 2007 Jul;28(7):1533-42. [2]. Deep G, et al. Isosilybin A induces apoptosis in human prostate cancer cells via targeting Akt, NF-κB, and androgen receptor signaling. Mol Carcinog. 2010 Oct;49(10):902-12.
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