Isosilybin A |
| Catalog No.GC36343 |
실리마린에서 분리된 플라보놀리그난인 이소실리빈 A는 항전립선암(PCA) 활성을 가지고 있습니다. 이소실리빈 A는 암세포에서 증식을 억제하고 G1 단계 정지 및 세포자멸사를 유도하여 Akt-NF-κB-안드로겐 수용체(AR) 축을 표적으로 하여 PCA 세포에서 세포자멸사 기계를 활성화합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 142796-21-2
Sample solution is provided at 25 µL, 10mM.
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Isosilybin A, a flavonolignan isolated from silymarin, has anti-prostate cancer (PCA) activity. Isosilybin A inhibits proliferation and induces G1 phase arrest and apoptosis in cancer cells, which activates apoptotic machinery in PCA cells via targeting Akt-NF-κB-androgen receptor (AR) axis[1][2].
[1]. Deep G, et al. Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostatecancer LNCaP and 22Rv1 cells. Carcinogenesis. 2007 Jul;28(7):1533-42. [2]. Deep G, et al. Isosilybin A induces apoptosis in human prostate cancer cells via targeting Akt, NF-κB, and androgen receptor signaling. Mol Carcinog. 2010 Oct;49(10):902-12.
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