Isosilybin A |
| カタログ番号GC36343 |
シリマリンから分離されたフラボノリグナンであるイソシリビン A には、抗前立腺癌 (PCA) 活性があります。イソシリビン A は増殖を阻害し、がん細胞の G1 期停止とアポトーシスを誘導します。これにより、Akt-NF-κB-アンドロゲン受容体 (AR) 軸を標的とすることで、PCA 細胞のアポトーシス機構が活性化されます。
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Cas No.: 142796-21-2
Sample solution is provided at 25 µL, 10mM.
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Isosilybin A, a flavonolignan isolated from silymarin, has anti-prostate cancer (PCA) activity. Isosilybin A inhibits proliferation and induces G1 phase arrest and apoptosis in cancer cells, which activates apoptotic machinery in PCA cells via targeting Akt-NF-κB-androgen receptor (AR) axis[1][2].
[1]. Deep G, et al. Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostatecancer LNCaP and 22Rv1 cells. Carcinogenesis. 2007 Jul;28(7):1533-42. [2]. Deep G, et al. Isosilybin A induces apoptosis in human prostate cancer cells via targeting Akt, NF-κB, and androgen receptor signaling. Mol Carcinog. 2010 Oct;49(10):902-12.
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