Pregnenolone monosulfate (Synonyms: 3β-Hydroxy-5-pregnen-20-one monosulfate) |
| Catalog No.GC36963 |
El monosulfato de pregnenolona (3β-Hidroxi-5-pregnen-20-uno monosulfato) es un neuroesteroide potente, el principal precursor de varias hormonas esteroides incluyendo cetonas esteroides.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1247-64-9
Sample solution is provided at 25 µL, 10mM.
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Pregnenolone monosulfate acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, reduces several effects of tetrahydrocannabinol (THC). CB1 Human Endogenous Metabolite
The effect of THC is significantly attenuated when slices are pre-treated with Pregnenolone 100 nM (15.1±1.8 % of inhibition). These effects are likely due to a pre-synaptic action of Pregnenolone. Thus, Pregnenolone blocks the increase in paired-pulse ratio (PPR) induced by THC but does not modify either the amplitude or the decay time of miniature EPSC (mEPSC)[1].
Pregnenolone administration (2-6 mg/kg) blocks THC-induced food-intake in Wistar rats and in C57BL/6N mice, and blunts the memory impairment induced by THC in mice, but it does not modify these behaviors per se. Injections of Pregnenolone (2 and 4mg/kg) before each self-administration session reduce the intake of WIN 55,212-2 and reduce the break-point in a progressive ratio schedule[1].
[1]. VallÉe M, et al. Pregnenolone can protect the brain from cannabis intoxication. Science. 2014 Jan 3;343(6166):94-8.
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