2-Methoxycinnamaldehyde |
| Catalog No.GC38318 |
El 2-MetoxicinamaldehÍdo (o-MetoxicinamaldehÍdo) es un compuesto natural de Cinnamomum cassia, con actividad antitumoral. El 2-metoxicinamaldehÍdo inhibe la proliferaciÓn e induce la apoptosis por pérdida del potencial de membrana mitocondrial (δψm), activaciÓn de caspasa-3 y caspasa-9. El 2-metoxicinamaldehÍdo inhibe eficazmente la migraciÓn de HASMC inducida por el factor de crecimiento derivado de plaquetas (PDGF).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1504-74-1
Sample solution is provided at 25 µL, 10mM.
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2-Methoxycinnamaldehyde (o-Methoxycinnamaldehyde) is a natural compound of Cinnamomum cassia, with antitumor activity[1][2][3]. 2-Methoxycinnamaldehyde inhibits proliferation and induces apoptosis by mitochondrial membrane potential (δψm) loss, activation of both caspase-3 and caspase-9[2]. 2-Methoxycinnamaldehyde effectively inhibits platelet-derived growth factor (PDGF)-induced HASMC migration[3].
[1]. Wong HY, et al. Cinnamomum verum Component 2-Methoxycinnamaldehyde: A Novel Anticancer Agent with Both Anti-Topoisomerase I and II Activities in Human Lung Adenocarcinoma A549 Cells In Vitro and In Vivo. Phytother Res. 2016 Feb;30(2):331-40. [2]. Liu YH, et al. Cinnamomum verum ingredient 2-methoxycinnamaldehyde: a new antiproliferative drug targeting topoisomerase I and II in human lung squamous cell carcinoma NCI-H520 cells. Eur J Cancer Prev. 2017 Jul;26(4):314-323. [3]. Jin YH, et al. 2-Methoxycinnamaldehyde inhibits the TNF-α-induced proliferation and migration of human aortic smooth muscle cells. Int J Mol Med. 2017 Jan;39(1):191-198.
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