2-Methoxycinnamaldehyde |
Katalog-Nr.GC38318 |
2-Methoxyzimtaldehyd (o-Methoxyzimtaldehyd) ist eine natÜrliche Verbindung von Cinnamomum cassia mit AntitumoraktivitÄt. 2-Methoxyzimtaldehyd hemmt die Proliferation und induziert Apoptose durch Verlust des mitochondrialen Membranpotentials (δψm), Aktivierung von Caspase-3 und Caspase-9. 2-Methoxyzimtaldehyd hemmt wirksam die durch den BlutplÄttchen-Wachstumsfaktor (PDGF) induzierte HASMC-Migration.
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Cas No.: 1504-74-1
Sample solution is provided at 25 µL, 10mM.
2-Methoxycinnamaldehyde (o-Methoxycinnamaldehyde) is a natural compound of Cinnamomum cassia, with antitumor activity[1][2][3]. 2-Methoxycinnamaldehyde inhibits proliferation and induces apoptosis by mitochondrial membrane potential (δψm) loss, activation of both caspase-3 and caspase-9[2]. 2-Methoxycinnamaldehyde effectively inhibits platelet-derived growth factor (PDGF)-induced HASMC migration[3].
[1]. Wong HY, et al. Cinnamomum verum Component 2-Methoxycinnamaldehyde: A Novel Anticancer Agent with Both Anti-Topoisomerase I and II Activities in Human Lung Adenocarcinoma A549 Cells In Vitro and In Vivo. Phytother Res. 2016 Feb;30(2):331-40. [2]. Liu YH, et al. Cinnamomum verum ingredient 2-methoxycinnamaldehyde: a new antiproliferative drug targeting topoisomerase I and II in human lung squamous cell carcinoma NCI-H520 cells. Eur J Cancer Prev. 2017 Jul;26(4):314-323. [3]. Jin YH, et al. 2-Methoxycinnamaldehyde inhibits the TNF-α-induced proliferation and migration of human aortic smooth muscle cells. Int J Mol Med. 2017 Jan;39(1):191-198.
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