Metaproterenol (hemisulfate) (Synonyms: dl-Metaproterenol, dl-Orciprenaline) |
| Catalog No.GC44169 |
El metaproterenol (hemisulfato) (hemisulfato de orciprenalina) es un simpaticomimético de acción directa y un agonista del receptor β2-adrenérgico (β2AR) con una IC50 de 68 nM.
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Cas No.: 5874-97-5
Sample solution is provided at 25 µL, 10mM.
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Metaproterenol is a β2-adrenergic receptor (β2-AR) agonist with bronchodilator actions. It inhibits TGF-α-induced hepatocyte DNA synthesis and proliferation in vitro (IC50 = 15 nM), an effect that is reversed by the β2-AR antagonist butoxamine but not the β1-AR antagonist metoprolol . Metaproterenol dose-dependently relaxes lung strips and increases heart rate and inotropy of right atria and left atria, respectively, isolated from guinea pig (pD2s = 6.4, 7.08, and 6.61, respectively). Formulations containing metaproterenol were previously used as long-acting bronchodilators for the treatment of asthma.
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