DNA Damage/DNA Repair

ARUK2010489 (Compound 23) is a potent, selective and brain-penetrant NUAK1 inhibitor with a pIC 50 of 8.7.

YL0441 is an inhibitor of ΔFOSB/JUND heterodimers and ΔFOSB homomultimers, with IC 50 values of 13.7 μM and 12.3 μM, respectively.

PD-L1/HDAC6-IN-1 TFA is an orally active dual inhibitor of PD-L1 and HDAC6, with IC 50 values of 26.8 nM and 78 nM, respectively.

JP-11646 is a pan-PIM inhibitor with increased potency against PIM2 ( IC 50 = 0.5 nM).

ETC-501 is a blood-brain barrier-permeable, orally active, and selective MNK1 / MNK2 inhibitor, with an IC 50 of 0.033 μM against MNK1 and 0.111 μM against MNK2.

QBS10072S dihydrochloride is a LAT1 -selective substrate with blood-brain barrier permeability that inhibits tumor growth.

PFKFB4-IN-1 is a potent and selective ATP-competitive PFKFB4 inhibitor ( IC 50 = 4.50 μM) that reduces intracellular PFKFB4 protein levels.

UDP-Glucosamine is a sugar nucleotide analog, glycosyl donor, and metabolite of D-galactosamine.

Cryptolepine is an orally active multi-potent alkaloid with anti-cancer, anti-bacterial, anti-viral, anti-malarial, anti-inflammatory, anti-hyperglycemic, relieve pain and other properties.

Gem-C12 is a prodrug of Gemcitabine.

Prexasertib -d 4 (LY2606368-d 4 ) is the deuterium labeled Prexasertib.

CHNQD-00824 is a Terphenyllin derivative with potent anticancer effect.

GS-441524 -d is the deuterium labeled GS-441524.

Irinotecan - 13 C 6 ((+)-Irinotecan- 13 C 6 ) is the 13 C-labeled Irinotecan.

antimetabolite and an antineoplastic agent.

Im-m7GDP sodium is a capping reagent and also the P-imidazolide of N7-methylguanosine 5'-diphosphate.

TK216 -d 4 is the deuterium labeled TK216.

Ac-QPKK(Ac)-AMC acetate is a p53-derived peptide conjugated with a fluorophore, which serves as a fluorescent peptide substrate for detecting the deacylase activity of zinc-dependent HDACs and sirtuins (Ex = 360 nm; Em = 460 nm) [1] .

Rucaparib -d 3 (AG014699-d 3 ) is the deuterated -labeled Rucaparib.

Sodium butyrate -d 3 (Butanoic acid-d 3 sodium) is the deuterium labeled Sodium butyrate.

Gartisertib -d 8 (VX-803-d 8 ) is the deuterium labeled Gartisertib.

PROTAC survivin degrader-1 is an orally active, CNS-penetrant survivin -targeting PROTAC.

ZLY025 is a potent and orally active CCNK molecular glue degrader with an DC 50 of 42.7 nM.

CXJ2080 is a selective PROTAC-based CDK7 degrader with a DC 50 of 0.88 nM.