GLPBio

DNA Damage/DNA Repair

Research Areas

Products Related to DNA Damage/DNA Repair(1968)

  • GC80885 structure
    GC80885PROTAC CDK6 Degrader 1
    Purity: >98.50%

    PROTAC CDK6 Degrader 1 (compound 48a) is a potent and selective PROTAC CDK6 degrader with a DC 50 of 0.037 μM.

  • GC80886 structure
    GC80886PROTAC CDK2/4/6 Degrader-2
    CAS: 2541626-49-5
    Purity: >97.00%

    PROTAC CDK2/4/6 Degrader-2 is a CDK2/4/6 PROTAC degrader.

  • GC80887 structure
    GC80887MA203
    Purity: >98%

    MA203 is a selective CHK1 PROTAC degrader.

  • GC80889 structure
    GC80889PROTAC HDAC4 Degrader-2
    CAS: 3035189-46-6
    Purity: >98%

    PROTAC HDAC4 Degrader-2 is a class IIa selective negative control for HDAC4 PROTAC degraders, with an IC 50 of 0.15 μM against HDAC4 and a cellular IC 50 of 0.18 μM.

  • GC80892 structure
    GC80892SR-5037
    CAS: 2387704-74-5
    Purity: >99.50%

    SR-5037 is an orally active CDK12 ( IC 50 = 31 nM)/ CDK13 inhibitor and CycK ( DC 50 = 30 nM; D max > 98%) molecular glue degrader.

  • GC80893 structure
    GC80893PROTAC CDK2/4 Degrader-1
    Purity: >98.00%

    PROTAC CDK2/4 Degrader-1 is a PROTAC degrader of cyclin-dependent kinase 2 ( CDK2 ) and cyclin-dependent kinase 4 ( CDK4 ).

  • GC80894 structure
    GC80894(S)-JWZ-5-13
    Purity: >99.50%

    (S)-JWZ-5-13 (compound 17-Neg), a PROTAC CDK7 degrader, is a negative control compound of JWZ-5-13.

  • GC80895 structure
    GC80895PROTAC USP39 Degrader-1
    Purity: >98.00%

    PROTAC USP39 Degrader-1 is a USP39 PROTAC degrader with K d values of 136 nM and 232 nM, and a DC 50 value of 1.06 nM (24 h).

  • GC80896 structure
    GC80896PROTAC D16-M1P2
    Purity: >98%

    PROTAC D16-M1P2 is an orally active CRBN -mediated selective PKMYT1 PROTAC degrader, with a DC 50 of 0.7 nM in CCNE1-amplified HCC1569 breast cancer cells.

  • GC80920 structure
    GC80920PROTAC PARP2 degrader-1
    CAS: 2925182-32-5
    Purity: >95.50%

    PROTAC PARP2 degrader-1 is an orally active PARP2 PROTAC degrader with a DC 50 of 2 μM.

  • GC80922 structure
    GC80922PROTAC HDAC6 degrader 7
    Purity: >98%

    PROTAC HDAC6 degrader 7 is an orally active, highly efficient, and selective PROTAC degrader targeting histone deacetylase 6 ( HDAC6 ) ( IC 50 = 118 nM).

  • GC80923 structure
    GC80923PROTAC HDAC degrader-2 TFA
    Purity: >96.50%

    PROTAC HDAC degrader-2 TFA is a selective class IIb dual histone deacetylase ( HDAC6 and HDAC10 ) PROTAC degrader, with DC 50 values of 13 nM and 29 nM against HDAC6 and HDAC10, respectively.

  • GC80924 structure
    GC80924iVeliparib-AP6
    CAS: 2472645-27-3
    Purity: >98%

    iVeliparib-AP6 is a proteolysis-targeting chimera ( PROTAC ) molecule designed based on Veliparib, which targets PARP1/2.

  • GC80930 structure
    GC80930DNMT1 Degrader-1
    CAS: 2962943-72-0
    Purity: >99.00%

    DNMT1 Degrader-1 is a selective DNMT1 degrader with an IC 50 of 202.87 nM and a Kd value of 122 nM.

  • GC81026 structure
    GC81026PROTAC SKP2 Degrader-1
    CAS: 3120650-15-6
    Purity: >99.50%

    PROTAC SKP2 Degrader-1 is a PROTAC degrader targeting SKP2, with a K d value of 6.28 μM.

  • GC81307 structure
    GC81307DYRK2-IN-2
    CAS: 2416195-65-6
    Purity: >98%

    DYRK2-IN-2 (Compound C17) is a selective inhibitor of DYRK2, with its IC 50 value being 40.3 nM.

  • GC81308 structure
    GC81308DYRK2-IN-2 hydrochloride
    Purity: >98.00%

    DYRK2-IN-2 hydrochloride is a selective DYRK2 inhibitor with an IC 50 of 40.3 nM.

  • GC81309 structure
    GC81309AO-365/43472821
    CAS: 1081122-55-5
    Purity: >99.50%

    AO-365/43472821 is a selective, brain-penetrant Dual-specificity tyrosine phosphorylation-regulated kinase 1A ( DYRK1A ) inhibitor ( IC 50 = 0.29 μM) and shows a significant inhibitory effect on ( CDC-like kinase 1) CLK1 ( IC 50 = 0.08 μM).

  • GC81312 structure
    GC81312PARP1/c-Met-IN-3
    CAS: 3123529-62-1
    Purity: >98%

    PARP1/c-Met-IN-3 (Compound L19) is a selective c-Met and PARP1 inhibitor, with an IC 50 of 5.4 nM against c-Met and an IC 50 of 3.7 nM against PARP1.

  • GC81336 structure
    GC81336KY19334
    CAS: 2319609-67-9
    Purity: >99.50%

    KY19334 is a CXXC5-DVL inhibitor.

  • GC81394 structure
    GC81394PPA-037 TFA
    Purity: >99.00%

    PPA-037 TFA is an orally active, highly potent and selective inhibitor of cyclin-dependent kinase 12 ( CDK12 ).

  • GC81395 structure
    GC81395ddhCTP trisodium solution (100 mM ± 3 mM)
    Purity: >98.00%

    ddhCTP trisodium solution (100 mM ± 3 mM) is an endogenously produced pyrimidine base analog with a K d of 17.0 nM for LLDH and an IC 50 of 55.8 μM for GAPDH.

  • GC81396 structure
    GC81396ARCA triammonium solution (100 mM)
    Purity: >98.00%

    ARCA (triammonium) solution (100 mM) (Anti-Reverse cap analog triammonium solution (100 mM); m 2 7,3'O Gppp triammonium solution (100 mM)) is a 5′-cap analog.

  • GC81397 structure
    GC813977-Methyl-diguanosine triphosphate ammonium solution (100 mM)
    CAS: 75252-12-9
    Purity: >98.50%

    7-Methyl-diguanosine triphosphate (m7Gp3G) ammonium is an mRNA cap structure analog that inhibits in vitro protein synthesis by binding to the translation initiation complex.