SJFα |
| Catalog No.GC33229 |
SJF& alfa; es un conector PROTAC de 13 átomos basado en el ligando de von Hippel-Lindau. SJF& alfa; degrada p38α con una DC50 de 7,16 nM, pero es mucho menos eficaz para degradar p38δ (DC50\u003d299 nM) y no degrada las otras isoformas de p38 (β y γ) en concentraciones de hasta 2,5 µM.
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Cas No.: 2254609-27-1
Sample solution is provided at 25 µL, 10mM.
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SJFα is a 13-atom linker PROTAC. SJFα degrades p38α with a DC50 of 7.16 nM, but is far less effective at degrading p38δ (DC50=299 nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5 µM[1].
[1]. Smith BE, et al. Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat Commun. 2019 Jan 10;10(1):131.
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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