SJFα |
| Catalog No.GC33229 |
SJF&알파; von Hippel-Lindau 리간드를 기반으로 하는 13개 원자 링커 PROTAC입니다. SJF&알파; 7.16 nM의 DC50으로 p38α를 분해하지만 p38δ(DC50\u003d299 nM)를 분해하는 데 훨씬 덜 효과적이며 최대 2.5 μM 농도에서 다른 p38 동형(β 및 γ)을 분해하지 않습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2254609-27-1
Sample solution is provided at 25 µL, 10mM.
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SJFα is a 13-atom linker PROTAC. SJFα degrades p38α with a DC50 of 7.16 nM, but is far less effective at degrading p38δ (DC50=299 nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5 µM[1].
[1]. Smith BE, et al. Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat Commun. 2019 Jan 10;10(1):131.
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