SJFα |
| カタログ番号GC33229 |
SJF&α;は、von Hippel-Lindau リガンドに基づく 13 原子リンカー PROTAC です。 SJF&α; 7.16 nM の DC50 で p38α を分解しますが、p38δ の分解効果ははるかに低く (DC50=299 nM)、2.5 μM までの濃度で他の p38 アイソフォーム (β および γ) を分解しません。
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Cas No.: 2254609-27-1
Sample solution is provided at 25 µL, 10mM.
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SJFα is a 13-atom linker PROTAC. SJFα degrades p38α with a DC50 of 7.16 nM, but is far less effective at degrading p38δ (DC50=299 nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5 µM[1].
[1]. Smith BE, et al. Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat Commun. 2019 Jan 10;10(1):131.
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