A12B4C3 |
| Catalog No.GC50097 |
A12B4C3 est un puissant inhibiteur de la polynucléotide kinase/phosphatase humaine (hPNKP) avec une valeur IC50 de 0,06 μM. A12B4C3 a une activité antiproliférative contre les cellules cancéreuses. A12B4C3 peut également augmenter la radiosensibilité de certaines cellules cancéreuses.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1005129-80-5
Sample solution is provided at 25 µL, 10mM.
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Potent and selective polynucleotide kinase/phosphatase (PNKP) inhibitor (IC50 = 60 nM). Displays no effect on calcineurin, protein PP-1 or APTX. Interrupts DNA repair and enhances radiosensitivity of human A549 lung carcinoma and MDA-MB-231 cells.
Freschauf et al (2009) Identification of a small molecule inhibitor of the human DNA repair enzyme polynucleotide kinase/phosphatase. Cancer Res. 69 7739 PMID:19773431 |Freschauf et al (2010) Mechanism of action of an imidopiperidine inhibitor of human polynucleotide kinase/phosphatase. J.Biol.Chem. 285 2351 PMID:19940137 |Schellenberg et al (2011) DNA end processing by polynucleotide kinase/phosphatase. Proc.Natl.Acad.Sci.U.S.A. 108 20855 PMID:22184240
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