A12B4C3 |
| Katalog-Nr.GC50097 |
A12B4C3 ist ein starker Hemmer der humanen Polynukleotidkinase/Phosphatase (hPNKP) mit einem IC50-Wert von 0,06 μM. A12B4C3 hat antiproliferative AktivitÄt gegen Krebszellen. A12B4C3 kann auch die Strahlenempfindlichkeit bestimmter Krebszellen erhÖhen.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1005129-80-5
Sample solution is provided at 25 µL, 10mM.
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Potent and selective polynucleotide kinase/phosphatase (PNKP) inhibitor (IC50 = 60 nM). Displays no effect on calcineurin, protein PP-1 or APTX. Interrupts DNA repair and enhances radiosensitivity of human A549 lung carcinoma and MDA-MB-231 cells.
Freschauf et al (2009) Identification of a small molecule inhibitor of the human DNA repair enzyme polynucleotide kinase/phosphatase. Cancer Res. 69 7739 PMID:19773431 |Freschauf et al (2010) Mechanism of action of an imidopiperidine inhibitor of human polynucleotide kinase/phosphatase. J.Biol.Chem. 285 2351 PMID:19940137 |Schellenberg et al (2011) DNA end processing by polynucleotide kinase/phosphatase. Proc.Natl.Acad.Sci.U.S.A. 108 20855 PMID:22184240
Average Rating: 5 (Based on Reviews and 24 reference(s) in Google Scholar.)
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