HaloPROTAC 2 (Synonyms: HaloPROTAC 2) |
| Catalog No.GC32831 |
HaloPROTAC 2 (HaloPROTAC 2) est un conjugué de ligands pour E3 et un lieur de 21 atomes de longueur. Le connecteur du lieur est le groupe halogène. HaloPROTAC 2 intègre le ligand VHL basé sur VH032 et le lieur PEG À 5 unités. HaloPROTAC 2 est capable d'induire la dégradation de GFP-HaloTag7 dans les tests cellulaires.
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Cas No.: 1799506-06-1
Sample solution is provided at 25 µL, 10mM.
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HaloPROTAC 2, a chloroalkane-containing PROTAC, induces degradation of HaloTag fusion proteins.
HaloPROTAC 1 and HaloPROTAC2, containing different linker lengths, are synthesized. Their ability to degrade GFP-HaloTag7, (stably expressed in HEK 293 cells) is tested tby flow cytometry, measuring changes in mean fluorescence intensity. While 24 hour treatment with HaloPROTAC 1 leads to less than 20% degradation, the longer HaloPROTAC2 leads to nearly 70% degradation of GFP-Halotag7 at 2.5 μM[1].
[1]. Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10(8):1831-7.
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