CP-96486 |
| Catalog No.GC31923 |
CP-96486 est un antagoniste des récepteurs du leucotriène D4 (LTD4)/facteur d'activation plaquettaire (PAF) puissant et actif par voie orale avec Kis de 20 et 24 nM, respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 139401-45-9
Sample solution is provided at 25 µL, 10mM.
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CP-96486 is a potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with Kis of 20 and 24 nM, respectively.
CP-96486 (CP-96,486) antagonizes 3H-LTD4 binding to guinea pig lung membranes and 3H-PAF binding to rabbit platelets with Ki's of 20 and 24 nM respectively[1].
CP-96486 (CP-96,486) inhibits iv LTD4- and iv PAF-induced bronchoconstriction in guinea pigs with ED50's of 0.27 and 0.26 mg/kg p.o. respectively[1].
[1]. A.Marfat,et al. The discovery of CP-96,021 and CP-96,486, balanced, combined, potent and orally active leukotriene D4(LTD4)/platelet activating factor (PAF) receptor antagonists.
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