CP-96486 |
| Katalog-Nr.GC31923 |
CP-96486 ist ein potenter und oral aktiver Leukotrien D4 (LTD4)/Thrombozytenaktivierungsfaktor (PAF)-Rezeptorantagonist mit Kis von 20 bzw. 24 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 139401-45-9
Sample solution is provided at 25 µL, 10mM.
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CP-96486 is a potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with Kis of 20 and 24 nM, respectively.
CP-96486 (CP-96,486) antagonizes 3H-LTD4 binding to guinea pig lung membranes and 3H-PAF binding to rabbit platelets with Ki's of 20 and 24 nM respectively[1].
CP-96486 (CP-96,486) inhibits iv LTD4- and iv PAF-induced bronchoconstriction in guinea pigs with ED50's of 0.27 and 0.26 mg/kg p.o. respectively[1].
[1]. A.Marfat,et al. The discovery of CP-96,021 and CP-96,486, balanced, combined, potent and orally active leukotriene D4(LTD4)/platelet activating factor (PAF) receptor antagonists.
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
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