D-AP5 (Synonyms: D-2-Amino-5-Phosphonovaleric acid; D-APV) |
| Catalog No.GC16315 |
Le D-AP5 (D-APV) est un antagoniste sélectif et compétitif des récepteurs NMDA avec un Kd de 1,4 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 79055-68-8
Sample solution is provided at 25 µL, 10mM.
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D-AP5 is a selective N-methyl-D-aspartate (NMDA) receptor antagonist (Kd = 1.4 μM) that competitively inhibits the glutamate binding site of NMDA receptors.[1] Whereas D-AP5 is the active (−)-stereoisomer, its (+)-isomer (L-AP5) demonstrates considerably less potent NMDA receptor antagonist activity.1 AP5 has been widely used to study the activity of NMDA receptors particularly in regard to researching synaptic plasticity, learning, and memory.[2]
Reference:
[1]. Evans, R.H., Francis, A.A., Jones, A.W., et al. The effects of a series of ω-phosphonic α-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations. Br. J. Pharmacol. 75(1), 65-75 (1982).
[2]. Morris, R.J. Synaptic plasticity and learning: Selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist AP5. J. Neurosci. 9(9), 3040-3057 (1989).
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