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ALK-IN-5

Catalog No.GC35289

ALK-IN-5 est un inhibiteur puissant, sélectif et pénétrant dans le cerveau de la kinase du lymphome anaplasique (ALK), avec une IC50 de 2,9 nM.

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ALK-IN-5 Chemical Structure

Cas No.: 2351929-66-1

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK), with an IC50 of 2.9 nM[1]. IC50: 2.9 nM (ALK)[1]

ALK-IN-5 potently inhibits ALK with cellular IC50 of 27 nM[1].

[1]. Fushimi M, et al. Discovery of Potent, Selective, and Brain-Penetrant 1 H-Pyrazol-5-yl-1 H-pyrrolo[2,3- b]pyridines as Anaplastic Lymphoma Kinase (ALK) Inhibitors. J Med Chem. 2019 May 23;62(10):4915-4935.

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Average Rating: 5 ★★★★★ (Based on Reviews and 7 reference(s) in Google Scholar.)

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