ALK-IN-5 |
| カタログ番号GC35289 |
ALK-IN-5 は、2.9 nM の IC50 を持つ未分化リンパ腫キナーゼ (ALK) の強力で選択的な脳浸透性阻害剤です 。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2351929-66-1
Sample solution is provided at 25 µL, 10mM.
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ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK), with an IC50 of 2.9 nM[1]. IC50: 2.9 nM (ALK)[1]
ALK-IN-5 potently inhibits ALK with cellular IC50 of 27 nM[1].
[1]. Fushimi M, et al. Discovery of Potent, Selective, and Brain-Penetrant 1 H-Pyrazol-5-yl-1 H-pyrrolo[2,3- b]pyridines as Anaplastic Lymphoma Kinase (ALK) Inhibitors. J Med Chem. 2019 May 23;62(10):4915-4935.
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)
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