JHU-083 |
Catalog No.GC36368 |
JHU-083, un promédicament de la 6-diazo-5-oxo-L-norleucine est un antagoniste de la glutaminase actif et sélectif par voie orale.
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Cas No.: 1998725-11-3
Sample solution is provided at 25 µL, 10mM.
JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells[1]. Blocking the function of glutaminase by the glutamine antagonist JHU-083 in experimental cerebral malaria (ECM) can result in a net decrease of glutamate levels in the animals[2]. Glutamine[2]
[1]. Zhu X, et al. JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress. Neuropsychopharmacology. 2019 Mar;44(4):683-694. [2]. Riggle BA, et al. MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12024-E12033.
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