JHU-083 |
| Catalog No.GC36368 |
JHU-083, a prodrug of 6-diazo-5-oxo-L-norleucine is an orally active and selective glutaminase antagonist.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1998725-11-3
Sample solution is provided at 25 µL, 10mM.
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JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells[1]. Blocking the function of glutaminase by the glutamine antagonist JHU-083 in experimental cerebral malaria (ECM) can result in a net decrease of glutamate levels in the animals[2]. Glutamine[2]
[1]. Zhu X, et al. JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress. Neuropsychopharmacology. 2019 Mar;44(4):683-694. [2]. Riggle BA, et al. MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12024-E12033.
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