MMV008138 |
| Catalog No.GC36637 |
MMV008138 est un agent antipaludéen ciblant IspD (enzyme 2-C-methyl-d-erythritol 4-phosphate cytidylyltransferase) sélectif d'espèce, avec une IC50 de 44 nM pour PfIspD (P.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1679333-73-3
Sample solution is provided at 25 µL, 10mM.
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MMV008138 is a species-selective antimalarial agent which targets the enzyme 2- C-methyl-d-erythritol 4-phosphate cytidylyltransferase (IspD) in the MEP pathway, with an IC50 of 250 nM for P. falciparum Dd2 strain[1][2]. IC50: 250 nM (P. falciparum Dd2 strain)[1]
[1]. Ghavami M, et al. Biological Studies and Target Engagement of the 2- C-Methyl-d-Erythritol 4-Phosphate Cytidylyltransferase (IspD)-Targeting Antimalarial Agent (1 R,3 S)-MMV008138 and Analogs. ACS Infect Dis. 2018 Apr 13;4(4):549-559. [2]. Yao ZK, et al. Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure-activity studies. Bioorg Med Chem Lett. 2015 Apr 1;25(7):1515-9.
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