LCB 03-0110 dihydrochloride |
Catalog No.GC50214 |
Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
Potent c-Src kinase inhibitor (IC50 = 1.3 nM). Also potent inhibitor of discoidin domain receptor 2 (DDR2) family tyrosine kinases, BTK and Syk. Suppresses LPS-induced activation of macrophages and TGF-β1- induced activation of fibroblasts in vitro. Also inhibits activation of macrophages and fibroblasts and suppresses scar formation in a wound healing model.
Sun et al (2012) LCB 03-0110, a novel pan-discoidin domain receptor/c-Src family tyrosine kinase inhibitor, suppresses scar formation by inhibiting fibroblast and macrophage activation. J.Pharmacol.Exp.Ther. 340 510 PMID:22128347
Average Rating: 5
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