LCB 03-0110 dihydrochloride |
| Katalog-Nr.GC50214 |
Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Potent c-Src kinase inhibitor (IC50 = 1.3 nM). Also potent inhibitor of discoidin domain receptor 2 (DDR2) family tyrosine kinases, BTK and Syk. Suppresses LPS-induced activation of macrophages and TGF-β1- induced activation of fibroblasts in vitro. Also inhibits activation of macrophages and fibroblasts and suppresses scar formation in a wound healing model.
Sun et al (2012) LCB 03-0110, a novel pan-discoidin domain receptor/c-Src family tyrosine kinase inhibitor, suppresses scar formation by inhibiting fibroblast and macrophage activation. J.Pharmacol.Exp.Ther. 340 510 PMID:22128347
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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