PROTAC Bcl2 degrader-1 |
Catalog No.GC38941 |
Le PROTAC Bcl2 degrader-1 (composé C5) est un PROTAC basé sur le ligand Cereblon, qui induit puissamment et sélectivement la dégradation de Bcl-2 (IC50, 4,94 μM; DC50, 3,0 μM) et Mcl-1 (IC50, 11.81 μM) en introduisant le ligand pomalidomide liant CRBN E3 ligase à l'inhibiteur double Nap-1 de Mcl-1/Bcl-2.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2378801-85-3
Sample solution is provided at 25 µL, 10mM.
PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1[1].
[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Aug 21.
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