PROTAC Bcl2 degrader-1 |
| Katalog-Nr.GC38941 |
PROTAC Bcl2 degrader-1 (Verbindung C5) ist ein auf Cereblon-Liganden basierender PROTAC, der selektiv und wirksam den Abbau von Bcl-2 (IC50, 4,94 μM; DC50, 3,0 μM) und Mcl-1 (IC50, 11.81 μM) durch Einführung des E3-Ligase-Cereblons (CRBN)-bindenden Liganden Pomalidomid zu dem Mcl-1/Bcl-2-Dualinhibitor Nap-1 induziert.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2378801-85-3
Sample solution is provided at 25 µL, 10mM.
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PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1[1].
[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Aug 21.
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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