QX77 |
| Catalog No.GC32962 |
QX77 est un activateur de l'autophagie médiée par le chaperon (CMA) et régule positivement l'expression de LAMP2A in vitro. QX77 induit la régulation À la hausse de Rab11, sauve la régulation À la baisse de Rab11 et le déficit de trafic dans les cellules cystinotiques. QX77 peut entraver l'auto-renouvellement et favoriser la différenciation des cellules ES.
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Cas No.: 1798331-92-6
Sample solution is provided at 25 µL, 10mM.
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QX77 is a chaperone-mediated autophagy (CMA) activator.
Treatment with CMA activator QX77 rescues Rab11 down-regulation and trafficking deficiency in cystinotic cells. QX77 treatment also increases LAMP2A localization at the lysosomal membrane[1].
[1]. Zhang J, et al. Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A. J Biol Chem. 2017 Jun 23;292(25):10328-10346.
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