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Accueil >> Signaling Pathways >> Proteases >> Lipoxygenase

Lipoxygenase

Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.

Targets for  Lipoxygenase

Products for  Lipoxygenase

  1. Cat.No. Nom du produit Informations
  2. GC48993 Protectin D1-d5 An internal standard for the quantification of protectin D1 Protectin D1-d5 Chemical Structure
  3. GC14847 Psoralidin La psoralidine est un double inhibiteur de COX-2 et 5-LOX, régule l'inflammation pulmonaire induite par les rayonnements ionisants (IR). Propriétés anticancéreuses, antibactériennes et anti-inflammatoires. La psoralidine régule significativement À la baisse la signalisation NOTCH1. La psoralidine induit également fortement la génération de ROS. Psoralidin Chemical Structure
  4. GC48035 RCTR1 A specialized pro-resolving mediator RCTR1 Chemical Structure
  5. GC41230 Resolvin D1 methyl ester L'ester méthylique de la résolvine D1 (ester méthylique RvD1) est l'ester méthylique de la résolvine D1. Resolvin D1 methyl ester Chemical Structure
  6. GC48041 Resolvin D1-d5 An internal standard for the quantification of RvD1 Resolvin D1-d5 Chemical Structure
  7. GC41231 Resolvin D2 methyl ester Resolvin D2 (RvD2) is a lipid mediator biosynthesized by the sequential oxygenation of docosahexaenoic acid by 15- and 5-lipoxygenase. Resolvin D2 methyl ester Chemical Structure
  8. GC48042 Resolvin D2-d5 An internal standard for the quantification of RvD2 Resolvin D2-d5 Chemical Structure
  9. GC41232 Resolvin D3 methyl ester Resolvin D3 methyl ester is a methyl ester version of the free acid that may act as a lipophilic prodrug form that will alter its distribution and pharmacokinetic properties. Resolvin D3 methyl ester Chemical Structure
  10. GC44818 Resolvin D4

    Resolvin D4 (RvD4) is a specialized pro-resolving mediator derived from docosahexaenoic acid.

     Resolvin D4 Chemical Structure
  11. GC40982 Resolvin D5

    Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.

     Resolvin D5 Chemical Structure
  12. GC48972 Resolvin E2 A specialized pro-resolving mediator Resolvin E2 Chemical Structure
  13. GC48045 Resolvin E4 A specialized pro-resolving mediator Resolvin E4 Chemical Structure
  14. GC41189 Ricinelaidic Acid Ricinelaidic acid is a 12-hydroxy fatty acid and an antagonist of leukotriene B4 (LTB4) receptors (Ki = 2 μM in porcine neutrophil membranes). Ricinelaidic Acid Chemical Structure
  15. GC31813 RWJ 63556 RWJ 63556 est un inhibiteur sélectif de la COX-2/5-lipoxygénase actif par voie orale, avec des activités anti-inflammatoires. RWJ 63556 Chemical Structure
  16. GC30027 S-(+)-Marmesin ((+)-Marmesin) La S-(+)-Marmesine ((+)-Marmesine) est une coumarine naturelle, présentant une double activité inhibitrice COX-2/5-LOX. S-(+)-Marmesin ((+)-Marmesin) Chemical Structure
  17. GC31835 S-2474 Le S-2474 est un inhibiteur de la COX-2 et de la 5-lipoxygénase (5-LO), avec des IC50 de 11 nM et 27 μM pour la COX-2 et la COX-1 dans les cellules humaines intactes, et utilisé comme anti-inflammatoire non stéroÏdien . S-2474 Chemical Structure
  18. GC44879 Sclerotiorin Sclerotiorin is a natural product isolated primarily from Penicillium species. Sclerotiorin Chemical Structure
  19. GC49386 Tepoxalin La tépoxaline est un double inhibiteur de la COX et de la 5-lipoxygénase (5-LO) avec une puissante activité anti-inflammatoire et un profil gastro-intestinal favorable. Tepoxalin Chemical Structure
  20. GC45024 tetranor-12(S)-HETE 12(S)-HETE is a product of arachidonic acid metabolism through the 12-lipoxygenase pathway. tetranor-12(S)-HETE Chemical Structure
  21. GC10451 U-73122

    Inhibiteur de la phospholipase C, de la phospholipase A2 et de 5-LO.

     U-73122 Chemical Structure
  22. GC41289 U-75302 U-75302 est un puissant inhibiteur du leucotriène B4. U-75302 Chemical Structure
  23. GC48659 Umbelliprenin A prenylated coumarin with diverse biological activities Umbelliprenin Chemical Structure
  24. GN10269 Wedelolactone Wedelolactone Chemical Structure
  25. GC16014 Zileuton Le zileuton est un inhibiteur puissant et sélectif de la 5-lipoxygénase aux propriétés antiasthmatiques. Zileuton Chemical Structure
  26. GC14435 Zileuton sodium Le zileuton sodique (A 64077 sodium) est un inhibiteur puissant et sélectif de la 5-lipoxygénase, présentant des activités inflammatoires. Zileuton sodium Chemical Structure
  27. GC48267 Zileuton-d4 An internal standard for the quantification of zileuton Zileuton-d4 Chemical Structure

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