TCV-309 chloride |
| Catalog No.GC33088 |
Le chlorure de TCV-309 est un antagoniste puissant et spécifique du facteur d'activation plaquettaire (PAF). Le chlorure de TCV-309 inhibe spécifiquement l'agrégation induite par le PAF des plaquettes de lapin et humaines, et la liaison du [3H]PAF aux microsomes plaquettaires de lapin avec des valeurs IC50 de 33 nM, 58 nM et 27 nM, respectivement. Le chlorure de TCV-309 a des effets bénéfiques en cas de choc anaphylactique.
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Cas No.: 121494-09-5
Sample solution is provided at 25 µL, 10mM.
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TCV-309 chloride is a platelet activating factor (PAF) antagonist. (1) TCV-309 chloride specifically inhibited PAF-induced aggregation of rabbit and human platelets. (2) TCV-309 chloride selectively inhibited the PAF-induced hypotension, hemoconcentration and death with ED50 values of 2.7, 6.4 and 1.7 micrograms/kg (i.v.), respectively. TCV-309 (chloride) most potently protected mice from death induced by PAF and due to anaphylactic shock with ED50 values of 2.1 and 2.6 micrograms/kg (i.v.), respectively. (3) TCV-309 chloride also reversed PAF-induced hypotension and endotoxin-induced hypotension in rats with ED50 values of 3.3 and 1.2 micrograms/kg (i.v.), respectively.
[1]. Terashita Z et al. Beneficial effects of TCV-309, a novel potent and selective platelet activating factor antagonist in endotoxin and anaphylactic shock in rodents. J Pharmacol Exp Ther. 1992 Feb;260(2):748-55.
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