TCV-309 chloride |
| カタログ番号GC33088 |
TCV-309 クロリドは、強力で特異的な血小板活性化因子 (PAF) 拮抗薬です。 TCV-309 クロリドは、ウサギおよびヒトの血小板の PAF 誘導凝集、およびウサギ血小板ミクロソームへの [3H]PAF 結合を、それぞれ 33 nM、58 nM、および 27 nM の IC50 値で特異的に阻害します。 TCV-309クロリドはアナフィラキシーショックに有益な効果があります。
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Cas No.: 121494-09-5
Sample solution is provided at 25 µL, 10mM.
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TCV-309 chloride is a platelet activating factor (PAF) antagonist. (1) TCV-309 chloride specifically inhibited PAF-induced aggregation of rabbit and human platelets. (2) TCV-309 chloride selectively inhibited the PAF-induced hypotension, hemoconcentration and death with ED50 values of 2.7, 6.4 and 1.7 micrograms/kg (i.v.), respectively. TCV-309 (chloride) most potently protected mice from death induced by PAF and due to anaphylactic shock with ED50 values of 2.1 and 2.6 micrograms/kg (i.v.), respectively. (3) TCV-309 chloride also reversed PAF-induced hypotension and endotoxin-induced hypotension in rats with ED50 values of 3.3 and 1.2 micrograms/kg (i.v.), respectively.
[1]. Terashita Z et al. Beneficial effects of TCV-309, a novel potent and selective platelet activating factor antagonist in endotoxin and anaphylactic shock in rodents. J Pharmacol Exp Ther. 1992 Feb;260(2):748-55.
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