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TCV-309 chloride

カタログ番号GC33088

TCV-309 クロリドは、強力で特異的な血小板活性化因子 (PAF) 拮抗薬です。 TCV-309 クロリドは、ウサギおよびヒトの血小板の PAF 誘導凝集、およびウサギ血小板ミクロソームへの [3H]PAF 結合を、それぞれ 33 nM、58 nM、および 27 nM の IC50 値で特異的に阻害します。 TCV-309クロリドはアナフィラキシーショックに有益な効果があります。

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TCV-309 chloride 化学構造

Cas No.: 121494-09-5

サイズ 価格 在庫数 個数
10mM (in 1mL DMSO)
$349.00
在庫あり
1mg
$108.00
在庫あり
5mg
$252.00
在庫あり
10mg
$396.00
在庫あり
50mg
$1,080.00
在庫あり
100mg
$1,512.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Description of TCV-309 chloride

TCV-309 chloride is a platelet activating factor (PAF) antagonist. (1) TCV-309 chloride specifically inhibited PAF-induced aggregation of rabbit and human platelets. (2) TCV-309 chloride selectively inhibited the PAF-induced hypotension, hemoconcentration and death with ED50 values of 2.7, 6.4 and 1.7 micrograms/kg (i.v.), respectively. TCV-309 (chloride) most potently protected mice from death induced by PAF and due to anaphylactic shock with ED50 values of 2.1 and 2.6 micrograms/kg (i.v.), respectively. (3) TCV-309 chloride also reversed PAF-induced hypotension and endotoxin-induced hypotension in rats with ED50 values of 3.3 and 1.2 micrograms/kg (i.v.), respectively.

[1]. Terashita Z et al. Beneficial effects of TCV-309, a novel potent and selective platelet activating factor antagonist in endotoxin and anaphylactic shock in rodents. J Pharmacol Exp Ther. 1992 Feb;260(2):748-55.

Chemical Properties of TCV-309 chloride

Cas No. 121494-09-5 SDF
Canonical SMILES CCC[N+]1=CC(C(N(CCC(NCCOC(N2CC3=C(C=CC=C3)CC2)=O)=O)C4=CC=CC=C4)=O)=CC(Br)=C1.[Cl-]
Formula C30H34BrClN4O4 M.Wt 629.97
溶解度 DMSO : ≥ 6.3 mg/mL (10.00 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of TCV-309 chloride

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1 mg 5 mg 10 mg
1 mM 1.5874 mL 7.9369 mL 15.8738 mL
5 mM 0.3175 mL 1.5874 mL 3.1748 mL
10 mM 0.1587 mL 0.7937 mL 1.5874 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 10 reference(s) in Google Scholar.)

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