TCV-309 chloride |
| Catalog No.GC33088 |
TCV-309 염화물은 강력하고 특정한 PAF(혈소판 활성화 인자) 길항제입니다. TCV-309 클로라이드는 각각 33nM, 58nM 및 27nM의 IC50 값으로 토끼 및 인간 혈소판의 PAF 유도 응집 및 토끼 혈소판 마이크로솜에 대한 [3H]PAF 결합을 특이적으로 억제합니다. TCV-309 염화물은 아나필락시성 쇼크에 유익한 효과가 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 121494-09-5
Sample solution is provided at 25 µL, 10mM.
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TCV-309 chloride is a platelet activating factor (PAF) antagonist. (1) TCV-309 chloride specifically inhibited PAF-induced aggregation of rabbit and human platelets. (2) TCV-309 chloride selectively inhibited the PAF-induced hypotension, hemoconcentration and death with ED50 values of 2.7, 6.4 and 1.7 micrograms/kg (i.v.), respectively. TCV-309 (chloride) most potently protected mice from death induced by PAF and due to anaphylactic shock with ED50 values of 2.1 and 2.6 micrograms/kg (i.v.), respectively. (3) TCV-309 chloride also reversed PAF-induced hypotension and endotoxin-induced hypotension in rats with ED50 values of 3.3 and 1.2 micrograms/kg (i.v.), respectively.
[1]. Terashita Z et al. Beneficial effects of TCV-309, a novel potent and selective platelet activating factor antagonist in endotoxin and anaphylactic shock in rodents. J Pharmacol Exp Ther. 1992 Feb;260(2):748-55.
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