Tyrphostin AG1433 (Synonyms: SU1433; AG1433) |
| Catalog No.GC39314 |
La tyrosine AG1433 (SU1433) est un inhibiteur des tyrosine kinases. AG1433 est également un inhibiteur sélectif de PDGFRβ et VEGFR-2 (Flk-1/KDR) avec des IC50 de 5,0 μM et 9,3 μM, respectivement. Tyrphostin AG1433 empêche la formation de vaisseaux sanguins.
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Cas No.: 168835-90-3
Sample solution is provided at 25 µL, 10mM.
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Tyrphostin AG1433 (SU1433) is a tyrosine kinases inhibitor. AG1433 is also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC50s of 5.0 μM and 9.3 μM, respectively. Tyrphostin AG1433 prevents blood vessel formation[1][2][3][4].
[1]. Serban F, et al. Silencing of epidermal growth factor, latrophilin and seven transmembrane domain-containing protein 1 (ELTD1) via siRNA-induced cell death in glioblastoma. J Immunoassay Immunochem. 2017;38(1):21-33. [2]. Strawn LM, et al. Flk-1 as a target for tumor growth inhibition. Cancer Res. 1996 Aug 1;56(15):3540-5. [3]. Kim TS, et al. The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress. Dis Model Mech. 2010 Nov-Dec;3(11-12):752-62. [4]. Kroll J, et al. The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. J Biol Chem. 1997 Dec 19;272(51):32521-7.
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