1-(4-Chlorobenzhydryl)piperazine (Synonyms: N-(p-Chlorobenzhydryl)-piperazine, Norchlorcyclizine, NSC 86164) |
| カタログ番号GC49294 |
メクリジンとクロルシクリジンの不活性代謝物
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 303-26-4
Sample solution is provided at 25 µL, 10mM.
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1-(4-Chlorobenzhydryl)piperazine is an inactive metabolite of meclizine and chlorcyclizine .1,2 It has also been found as an impurity in commercial preparations of hydroxyzine and cetirizine .3,4 1-(4-Chlorobenzhydryl)piperazine has been used in the synthesis of voltage-gated sodium channel 1.7 (Nav1.7) inhibitors, anticancer agents, and antihistamines.5,6,7
1.Gaertner, H.J., Breyer, U., and Liomin, G.Chronic administration of chlorcyclizine and meclizine to rats: Accumulation of a metabolite formed by piperazine ring cleavageJ. Pharmacol. Exp. Ther.185(2)195-201(1973) 2.Kuntzman, R., Klutch, A., Tsai, I., et al.Physiological distribution and metabolic inactivation of chlorcyclizine and cyclizineJ. Pharmacol. Exp. Ther.149(1)29-35(1965) 3.Simpson, D., Skellern, G.G., and Miller, J.H.Method for the control of known impurities in hydroxyzine hydrochlorideJ. Pharm. Biomed. Anal.14(8-10)1371-1375(1996) 4.Javid, F.S., Shafaat, A., and Zarghi, A.Determination of cetirizine and its impurities in bulk and tablet formulation using a validated capillary zone electrophoretic methodJ. Anal. Chem.69(5)442-447(2014) 5.Back, S.K., Kam, Y.L., Oh, J.A., et al.Synthesis and evaluation of (4-chlorobenzhydryl) piperazine amides as sodium channel Nav1.7 inhibitorsBull. Korean Chem. Soc.36(9)2290-2297(2015) 6.Yarim, M., Koksal, M., Durmaz, I., et al.Cancer cell cytotoxicities of 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine derivativesInt. J. Mol. Sci.13(7)8071-8085(2012) 7.Narsaiah, A.V., and Narssimha, P.Efficient synthesis of antihistamines clocinizine and chlorcyclizineMed. Chem. Res.21538-541(2012)
| Cas No. | 303-26-4 | SDF | |
| 同義語 | N-(p-Chlorobenzhydryl)-piperazine, Norchlorcyclizine, NSC 86164 | ||
| Canonical SMILES | ClC1=CC=C(C(N2CCNCC2)C3=CC=CC=C3)C=C1 | ||
| Formula | C17H19ClN2 | M.Wt | 286.8 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml,Ethanol: 25 mg/ml | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.4868 mL | 17.4338 mL | 34.8675 mL |
| 5 mM | 0.6974 mL | 3.4868 mL | 6.9735 mL |
| 10 mM | 0.3487 mL | 1.7434 mL | 3.4868 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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