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2',3'-Dideoxyadenosine 5'-triphosphate (Synonyms: 2',3'-Dideoxyadenosine 5'-triphosphate)

カタログ番号GC42061

2',3'-Dideoxyadenosine 5'-triphosphate (2',3'-Dideoxyadenosine 5'-triphosphate), an active metabolite of 2',3'-dideoxyinosine, is a chain-elongating inhibitor of DNA polymerase.

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2',3'-Dideoxyadenosine 5'-triphosphate 化学構造

Cas No.: 24027-80-3

サイズ 価格 在庫数 個数
100μL(10 mM in  water)
$182.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Description of 2',3'-Dideoxyadenosine 5'-triphosphate

2',3'-Dideoxyadenosine 5'-triphosphate (ddATP) is an in vitro inhibitor of reverse transcriptases from retroviruses, including HIV-1 and visna (Kis = 20 and 37 nM, respectively). It also blocks, in vitro, mammalian and bacterial DNA polymerases. ddATP, produced intracellularly by the phosphorylation of exogenously supplied 2',3'-dideoxyadenosine, competes with dATP, resulting in chain termination. Because of this activity, dideoxynucleoside 5'-triphosphates, including ddATP, are used to terminate chain extension produced by the Taq polymerase used in polymerase chain reactions. It is also an antagonist of the purinergic receptor P2X2/3 (pIC50 = 6.5).

Chemical Properties of 2',3'-Dideoxyadenosine 5'-triphosphate

Cas No. 24027-80-3 SDF
同義語 2',3'-Dideoxyadenosine 5'-triphosphate
Canonical SMILES O=P(OP(OP(O)(O)=O)(O)=O)(O)OC[C@@H]1CC[C@H](N2C=NC3=C2N=CN=C3N)O1
Formula C10H16N5O11P3 M.Wt 475.2
溶解度 Water: soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 2',3'-Dideoxyadenosine 5'-triphosphate

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1 mg 5 mg 10 mg
1 mM 2.1044 mL 10.5219 mL 21.0438 mL
5 mM 0.4209 mL 2.1044 mL 4.2088 mL
10 mM 0.2104 mL 1.0522 mL 2.1044 mL
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In vivo Formulation Calculator (Clear solution) of 2',3'-Dideoxyadenosine 5'-triphosphate

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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