(2S)-OMPT |
| カタログ番号GC41692 |
リゾホスファチジン酸（LPA）は、LPA1 / EDG-2、LPA2 / EDG-4、LPA3 / EDG-7およびLPA4 / GPR23の4つの異なる受容体を介して効果を発揮する強力な脂質中間体です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1217471-69-6
Sample solution is provided at 25 µL, 10mM.
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Lysophosphatidic acid (LPA) is a potent lipid mediator that elicits its effect through four distinct receptors - LPA1/EDG-2, LPA2/EDG-4, LPA3/EDG-7 and LPA4/GPR23. OMPT is a selective agonist of the lysophosphatidic acid 3 (LPA3) receptor. It exhibits EC50 values of 68 nM and >6.8 µM for calcium mobilization in LPA1 and LPA2-expressing Sf9 cells, respectively. The (2S)-OMPT enantiomer is 5- to 20-fold more active than (2R)-OMPT in calcium release assays in both LPA3-transfected Sf9 and rat hepatoma Rh7777 cells.
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