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3-Deoxy-D-glycero-D-galacto-2-nonulosonic Acid (Synonyms: Deaminoneuraminic acid)

カタログ番号GC42261

シアル酸は、糖タンパク質の末端炭水化物として一般的に存在し、細胞接着や信号認識などの様々な細胞機能、および腫瘍の形成と進行に必要です。

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3-Deoxy-D-glycero-D-galacto-2-nonulosonic Acid 化学構造

Cas No.: 153666-19-4

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Sample solution is provided at 25 µL, 10mM.

Description of 3-Deoxy-D-glycero-D-galacto-2-nonulosonic Acid

Sialic acids, commonly present as terminal carbohydrates on glycoconjugates, are essential for a variety of cellular functions including cell adhesion and signal recognition, as well as the formation and progression of tumors. 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid is a deaminated sialic acid that was first identified at the nonreducing ends of oligosialyl chains in rainbow trout egg glycoprotein.[1] It is thought to be a precursor for the biosynthesis of other members of the sialic acid family.[2] 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid can be used to analyze nonulosonic acid residues in polysialoglycoproteins.[1]

Reference:
[1]. Nadano, D., Iwasaki, M., Endo, S., et al. A naturally occurring deaminated neuraminic acid, 3-deoxy-D-glycero-D-galacto-nonulosonic acid (KDN). Its unique occurrence at the nonreducing ends of oligosialyl chains in polysialoglycoprotein of rainbow trout eggs. The Journal of Biological Chemisty 261(25), 11550-11557 (1986).
[2]. Münster-Kühnel, A.K., Tiralongo, J., Krapp, S., et al. Structure and function of vertebrate CMP-sialic acid synthetases. Glycobiology 14(10), 43R-51R (2004).

Chemical Properties of 3-Deoxy-D-glycero-D-galacto-2-nonulosonic Acid

Cas No. 153666-19-4 SDF
同義語 Deaminoneuraminic acid
Chemical Name 3-deoxy-D-glycero-D-galacto-2-nonulopyranosonic acid
Canonical SMILES O[C@H]1CC(C(O)=O)(O)O[C@]([C@H](O)[C@H](O)CO)([H])[C@@H]1O
Formula C9H16O9 M.Wt 268.2
溶解度 30mg/mL in DMSO, 10mg/mL in DMF Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 3-Deoxy-D-glycero-D-galacto-2-nonulosonic Acid

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1 mg 5 mg 10 mg
1 mM 3.7286 mL 18.6428 mL 37.2856 mL
5 mM 0.7457 mL 3.7286 mL 7.4571 mL
10 mM 0.3729 mL 1.8643 mL 3.7286 mL
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