3-hydroxy-4-Methoxyphenethylamine (hydrochloride) (Synonyms: 4-O-methyl Dopamine, p-methoxy Dopamine, para-methoxy Dopamine, 4-methoxy-3-Hydroxyphenethylamine)

3-hydroxy-4-Methoxyphenethylamine is a metabolite of the catecholamine dopamine .¹ It is formed from dopamine by catechol-O-methyltransferase (COMT). 3-hydroxy-4-Methoxyphenethylamine (200 µM) decreases the viability of SH-SY5Y cells.² It induces tachycardia and increases blood pressure in normotensive or DOCA-salt hypertensive rats when administered at a dose of 1 mg/kg.³ 3-hydroxy-4-Methoxyphenethylamine (100 mg/kg) induces tremors and rigidity in mice.⁴

1.Shoup, R.E., Davis, G.C., and Kissinger, P.T.Determination of catechol-O-methyltransferase activity in various tissues by liquid chromatographyAnal. Chem.52(3)483-487(1980) 2.Haque, M.E., Asanuma, M., Higashi, Y., et al.Apoptosis-inducing neurotoxicity of dopamine and its metabolites via reactive quinone generation in neuroblastoma cellsBiochim. Biophys. Acta1619(1)39-52(2003) 3.Gregson, R.P., Lohr, R.R., Marwood, J.F., et al.3-Hydroxy-4-methoxyphenethylamine, the cardioactive constituent of a soft coralExperientia37(5)493-494(1981) 4.Spoerlein, M.T., and VanderWende, C.Nature of the tremors induced by p-methoxydopamineLife Sci.6(19)2029-2035(1967)