5-HT3 antagonist 5 |
| カタログ番号GC65983 |
5-HT3 アンタゴニスト 5 は、5-HT3 受容体アンタゴニストであるキノキサリン-2-カルボキサミド化合物です。 5-HT3 アンタゴニスト 5 は、5-HT3 アゴニストと 2-メチル-5-HT に拮抗し、マウスで抗うつ効果を示します。
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Cas No.: 901599-43-7
Sample solution is provided at 25 µL, 10mM.
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5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a 5-HT3 receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on 5-HT3 agonist and 2-methyl-5-HT, and shows anti-depressant effect in mice[1].
5-HT3 antagonist 5 (compound 4c) exhibits 5-HT3 receptor antagonisms in longitudinal muscle myenteric plexus preparation from guinea pig ileum against 5-HT3 agonist, 2-methyl-5-HT, with pA2 value of 5[1].
5-HT3 antagonist 5 (compound 4c) (1 mg/kg; i.p.; single dose) decreases the duration of immobility and shows anti-depressant effect in FST mice[1].
| Animal Model: | Swiss albino mice (23 ± 2 g)[1] |
| Dosage: | 1 mg/kg |
| Administration: | Intraperitoneal injection; single dose; locomotor scores tested 10 min after administration |
| Result: | Reduced the duration of immobility as compared to the vehicle-treated (control) group. Showed no effect on the locomotion of mice as observed in spontaneous locomotor activity. |
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