5-HT3 antagonist 5 |
| Catalog No.GC65983 |
5-HT3 길항제 5는 5-HT3 수용체 길항제인 퀴녹살린-2-카르복스아미드 화합물입니다. 821d96072c2d58d8970e76f526b0f6b85-HT3 길항제 5는 5-HT3 작용제 및 2-메틸-5-HT에 대해 길항 작용을 하며 마우스에서 항우울 효과를 나타낸다.821d96072c2d58d8970e76f526b0f6b8
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 901599-43-7
Sample solution is provided at 25 µL, 10mM.
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5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a 5-HT3 receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on 5-HT3 agonist and 2-methyl-5-HT, and shows anti-depressant effect in mice[1].
5-HT3 antagonist 5 (compound 4c) exhibits 5-HT3 receptor antagonisms in longitudinal muscle myenteric plexus preparation from guinea pig ileum against 5-HT3 agonist, 2-methyl-5-HT, with pA2 value of 5[1].
5-HT3 antagonist 5 (compound 4c) (1 mg/kg; i.p.; single dose) decreases the duration of immobility and shows anti-depressant effect in FST mice[1].
| Animal Model: | Swiss albino mice (23 ± 2 g)[1] |
| Dosage: | 1 mg/kg |
| Administration: | Intraperitoneal injection; single dose; locomotor scores tested 10 min after administration |
| Result: | Reduced the duration of immobility as compared to the vehicle-treated (control) group. Showed no effect on the locomotion of mice as observed in spontaneous locomotor activity. |
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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