5-hydroxymethyl Tolterodine (formate) (Synonyms: 5-HMT, Desfesoterodine, PNU 200577) |
| カタログ番号GC42551 |
5-ヒドロキシメチルトルテロジンは、ムスカリン性アセチルコリン受容体拮抗薬であるトルテロジンとフェソテロジンの有効代謝物質です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 380636-49-7
Sample solution is provided at 25 µL, 10mM.
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5-hydroxymethyl Tolterodine is an active metabolite of the muscarinic acetylcholine receptor antagonists tolterodine and fesoterodine . It is formed from tolterodine by the cytochrome P450 (CYP) isoform CYP2D6 and from fesoterodine by plasma esterases. 5-hydroxymethyl Tolterodine inhibits M1-5 muscarinic receptors with Ki values of 2.3, 2, 2.5, 2.8, and 2.9 nM, respectively, for the human receptors expressed in CHO cells. It selectively inhibits acetylcholine-induced bladder contraction over electrically induced salivation in anesthetized cats (ID50s = 15 and 40 nmol/kg, respectively).
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